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Also, the release of inflammatory cytokines in response to the virus could disrupt the BBBs normal function and increase its permeability leading to more CNS infection [11]

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The risk is that you now have multiple open vials aging simultaneously, and if your dosing schedule does not consume them all within 28 days, you waste peptide

Li et al., 2022)

The GDNF family: signalling, biological functions and therapeutic value

Keep the vial away from the freezer compartment and the coldest back corner of the fridge where accidental freezing can happen